Publication date: 15 February 2017
Source:Journal of Crystal Growth, Volume 460
Author(s): Wei-Yi Wu, Chie-Shaan Su
In this study, the supercritical antisolvent (SAS) process was used to recrystallize an active pharmaceutical ingredient, sulfasalazine, to modify the solid-state properties including particle size, crystal habit and polymorphic form. Supercritical CO2 and tetrahydrofuran were used as the antisolvent and solvent, respectively. SAS results obtained from different operating temperatures (35, 45, 55 and 652 and tetrahydrofuran. Operation at slightly higher than the MCP is favorable for recrystallization of sulfasalazine through SAS. These results demonstrate that the SAS process is an efficient tool for controlling and modifying the solid-state property of sulfasalazine.
Source:Journal of Crystal Growth, Volume 460
Author(s): Wei-Yi Wu, Chie-Shaan Su